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A volunteer-driven nonprofit providing low-cost spay/neuter clinics, animal adoption/fostering, cruelty investigations, and Trap-Neuter-Return programs for feral cats in Athens County since 1910.

The first organization, by its own description, dedicated exclusively to improving the welfare of the ~440 billion shrimp farmed each year, deploying humane electrical stunners and pushing producers away from cruel practices like eyestalk ablation.

Accelerates the academic field of wild animal welfare science through original research, grantmaking, and professional outreach to identify evidence-based interventions for improving wild animals' wellbeing.

Reduces the suffering of farmed fishes by researching, testing and implementing welfare improvements — chiefly better water quality and lower stocking density — with partner farms in India, where most of its work happens, and a small team in China.

Drives systems-level change for trillions of farmed and wild-caught aquatic animals by reforming seafood certification schemes and building the Aquatic Animal Alliance coalition.

Reduces farmed animal suffering across the Global South through corporate cage-free and pig-welfare campaigns, undercover factory farm investigations and plant-based institutional meals, with national teams in Argentina, Brazil, Colombia, Indonesia and Thailand.

Protects wildlife and habitat across nearly two million acres of the Amboseli-Tsavo-Kilimanjaro ecosystem on the Kenya–Tanzania border, using community-based Maasai ranger patrols, snare removal and work to resolve conflicts between people and wildlife.

Protects bats and their habitats worldwide through evidence-based conservation and cutting-edge research, recognizing bats as vital pollinators and pest controllers.

Builds teams of women rangers to protect wildlife and wild landscapes in Zimbabwe, Mozambique and Botswana, reporting more than 13.1 million acres under management and a 90% decline in elephant poaching in its Zimbabwe operations.

An all-volunteer 501(c)(3) food pantry in Nelsonville that has served Athens County residents since 1989, giving more than 600 families a month a 3-day supply of groceries in Ohio's Appalachian southeast.

A volunteer-run nonprofit fighting food insecurity in Athens County since 1980, bolstered by the Joe Burrow Hunger Relief Fund endowment.

A community action agency empowering Hocking, Athens, and Perry counties through the SE Ohio Foodbank (serving 10 counties), Head Start early childhood education, energy assistance, housing, and transportation.

A small U.S. 501(c)(3) working in low-income neighborhoods of northern Medellín, running an ambulance and emergency-response service (Emergencias Apolo), coding classes (Recode the Future), food package deliveries and a Christmas toy program.

Fights hunger and poverty by cooking scratch-made meals for D.C. shelters, nonprofits, youth programs and public schools — about 6.2 million in 2025 — while training adults facing barriers to employment for food-service careers.

Uses its own volunteer-powered Food Rescue Hero app to redirect fresh surplus food from retailers to nonprofits serving people facing food insecurity in roughly 30-minute rescue runs, fighting hunger and food waste at the same time.

A faith-based, volunteer-powered nonprofit that supplies food to about 2,400 local pantries, kitchens, shelters and other nonprofits from 12 locations across the U.S., East Africa and Haiti, distributing 139 million pounds of food in the past year.

Engages volunteers to package nutritious meals for school feeding and other hunger programs while investing in longer-term food security, such as helping smallholder farmers in Malawi, with operations in the U.S., India, Italy, Malaysia, the Philippines, Singapore and South Africa.

Helps rural communities in nine African countries, Bangladesh, India and Mexico end their own hunger by starting with women, mobilizing local leadership and engaging local government. In Africa it groups villages into self-reliant 'epicenters'.

Funds long-lasting insecticide-treated bed nets for malaria-endemic countries, mainly in sub-Saharan Africa and Papua New Guinea, relying on partner organizations to distribute them, with 100% of public donations buying nets.

Delivers seasonal malaria chemoprevention — preventive antimalarial medicine given door to door by community distributors during the rainy-season peak — to young children in seven African countries, reaching 22.5 million children in 2024.

Supports government-run campaigns that give children aged 6 to 59 months a vitamin A capsule twice a year, mostly in sub-Saharan Africa, through funding, training, planning and monitoring — reaching 47 million children in 18 countries in the most recent year.

Increases routine childhood vaccination rates in Nigeria by providing small conditional cash transfers to families who bring their children for immunizations.

Funds surgical repair of obstetric fistula — a childbirth injury that leaves women incontinent — through 102 vetted hospitals and outreach partners in 36 countries across Africa and Asia, and says it funds more fistula surgeries than any other organization.

Trains community health workers — predominantly women — to deliver life-saving medicines, diagnoses, and health education directly to families' doorsteps, preventing the leading causes of child death.

A global eye care nonprofit that restores sight and prevents blindness in underserved communities across 20+ countries in Asia, Africa, and the Americas.

Reduces educational inequality by delivering robotics, English, digital skills, socio-emotional learning and career guidance to 8,000+ low-income students in 31 urban and rural public schools in Medellín and the Nuquí region of Colombia's Pacific coast.

An Indian education nonprofit that uses its 'Teaching at the Right Level' approach to help children master reading and basic math, runs the ASER learning survey, and offers second-chance schooling and vocational training across 24 Indian states and union territories.

Tackles poverty and inequality in sub-Saharan Africa by supporting marginalized girls to attend school and transition into confident young women leaders through its alumnae network (CAMA) of 355,000+ women.

Mobilizes 23,000+ community volunteers across 30,000+ villages in rural India to enroll out-of-school girls and improve foundational literacy and numeracy, and ran what it describes as the world's first Development Impact Bond in education.

Now part of Girl Rising after an October 2025 merger, She's the First advances girls' education and leadership by partnering with 900 community organizations and 295 girl-led chapters in 62 countries on mentorship, leadership training and staff capacity-building.

A Saint Paul, Minnesota nonprofit that collects donated textbooks and library books and ships them by sea container to partner schools and libraries across Africa, sending more than 65 million books since 1988.

Scales Pratham's evidence-backed Teaching at the Right Level approach across Africa, training government school teachers to assess children and teach to their actual learning level rather than their grade to close gaps in foundational literacy and numeracy.

A London-based charity that sets up free, community-led primary schools in remote, marginalized areas of Cambodia, Nepal, Myanmar and Madagascar. It trains teachers in basic literacy and numeracy and works with local governments.

A membership-based nonprofit in The Plains that has worked since 1991 to build a healthier economy and environment across Appalachian Ohio through sustainable agriculture, forestry, watershed restoration, zero-waste initiatives and environmental education.

Pushes for the policies and technologies needed to decarbonize the whole economy, from methane pollution and carbon capture to advanced nuclear, hydrogen and superhot rock geothermal, pairing technical analysis with advocacy across the U.S., Europe, Africa and MENA.

Decarbonizes aviation and maritime shipping — historically overlooked sectors — by leveraging industry coalitions, direct advocacy, and legal frameworks.

Fights plastic pollution through science, education and advocacy, running lab research, TrashBlitz community trash audits and a global ambassador network; co-founder Marcus Eriksen led the 2014 study estimating at least 5.25 trillion plastic particles afloat in the world's oceans.

Helps smallholder farming families in Kenya, Uganda and Tanzania restore degraded land through its Forest Garden Approach, training them to combine trees and regenerative agriculture to grow enough nutrient-rich food to eat and sell.

Pools donations and channels them as grants directly to community-led grassroots groups protecting the environment and the rights of people who depend on it, guided by volunteer experts — more than 20,000 grants in 168 countries since 1993.

A West Harlem–based environmental justice group, founded in 1988, that organizes residents and advocates at the city, state and federal levels so people of color and low-income communities help shape the environmental health policies affecting them.

A US-based 501(c)(3), launched in 2022, working to speed geothermal energy's global growth by shifting oil-and-gas resources, technology and know-how into geothermal, backed by its GeoMap resource map, early-stage project funding and policy research.

Installs and maintains 53,000+ chlorine dispensers at communal water points in rural Kenya, Uganda and Malawi, plus in-line chlorinators in India, giving nearly 10 million people safe water at a reported cost under $1.70 per person per year.

Transforms lives through sustainable access to safe water, improved sanitation, and hygiene in hard-to-reach places, using a "Vision of a Healthy Village" model emphasizing community partnership and long-term maintenance; it merged with Lifewater International in 2024.

Brings piped water connections and toilets into homes in low-income communities in Bangladesh, Honduras and Kenya through local partner organizations, and reports that 99% of its 5,000 projects remain operational.

Provides clean, safe, reliable water across sub-Saharan Africa with transparency — donors can sponsor specific communities and receive live impact reports with maps, photos, and stories.

Helps communities set up, own and run water purification systems that use ultrafiltration or reverse-osmosis membranes to remove bacteria, viruses, cysts and parasites, with 417 current projects in 16 countries.

Deploys gravity-fed AquaTower filtration systems in schools and communities, each producing about 1,000 liters of drinking water per hour and able to meet the daily drinking needs of up to 1,800 people, paired with handwashing taps and hygiene education.

Works to achieve lasting, universal water and sanitation coverage in entire districts across 10 countries through its "Everyone Forever" model, partnering with local governments, businesses, and communities.

Since 1999, has supported at-risk young people in Appalachian Ohio through foster care, emergency youth shelters, YouthBuild job-readiness training and academic help, and the Sojo Resiliency Center in Athens, a drop-in space for ages 12–21.

A Denver-based US 501(c)(3) that funds community-led projects in and around Medellín, Colombia, focused on children's nutrition, education, health care and safety, including a neighborhood soup kitchen, a youth soccer program and a children's home.

Founded in 2008, this Dutch-Colombian foundation promotes the social integration of 450+ children disadvantaged by poverty, violence, and addiction through comprehensive educational, sports, and cultural programs in Medellín's hillside comunas.

Aims to break the cycle of generational poverty by pairing children with salaried, professional mentors from pre-kindergarten through graduation — a 12+ year commitment, "no matter what" — across 42 locations nationwide.

Finds, funds and strengthens small grassroots organizations working with children and young people facing adversity, granting $7.4M+ to 293 partners in 40 countries in 2022–23; its partners have spanned more than 90 countries.

Journeys alongside children impacted by trafficking and works to prevent it through survivor care in the US and the Philippines and its "Not a Number" prevention curriculum, which has facilitators in 21 US states.

Helps older children in foster care and orphanages find caring adults and, where possible, permanent families through its Family Visit Model and mentoring in the US and Colombia, emergency evacuation work in Ukraine, and family reunification in Sierra Leone.

A feminist NGO founded in 1979 in Medellín that defends women's human rights in the city and three Antioquia subregions through work on economic empowerment, a life free from violence, and women's political participation, plus an annual rights-violations report.

Combats human trafficking by supplying local police with investigators, covert equipment and funding to gather evidence, training officers and communities to recognize trafficking, and supporting survivors through aftercare.

Works to end modern slavery by changing the conditions that allow it, using its Community Liberation Model to educate at-risk communities, support survivors' recovery, strengthen the rule of law and link to essential services.

Uses legal advocacy to protect and promote the human rights of women and girls worldwide — challenging discriminatory laws, holding governments accountable, and driving legal reform for gender equality.

Works to end sex and labor trafficking in North America through data analysis, financial-intelligence reports on trafficking networks, public and business training, and policy advocacy — after running the U.S. National Human Trafficking Hotline from 2007 to 2025.

Advocates for the human rights of LGBTIQ people worldwide, partnering with local groups across Africa, Asia and the Pacific, Southwest Asia and North Africa, Europe and Central Asia, and the Americas to document abuses and press for equality.

Works to prevent human trafficking and help survivors rebuild by creating pathways to safe jobs, offering women and girls life skills, financial literacy, job training, placement and mentorship in India, Cambodia and Texas.

Combines intelligence, military and law-enforcement expertise with technology to spot likely trafficking in illicit online ads, giving police intelligence reports, software tools and training to identify and arrest human traffickers.

Volunteer-powered organization providing immediate disaster response and long-term recovery by rebuilding homes, schools and community infrastructure; it reports mobilizing more than 71,000 volunteers across 32 countries.

Focuses on long-term disaster recovery, helping families get back into safe, repaired homes through its Homeowner Recovery Services and advising communities on running recovery programs through its Community Advisory Services.

Deploys emergency medical teams, medicines, point-of-care labs and hygiene kits to disaster zones and medically underserved communities; in 2023 the WHO verified it as a Type 1 Mobile Emergency Medical Team, which it says made it the fourth U.S. team so designated.

Rescues and repurposes surplus products from corporations, manufacturers and the public — food, clothing, personal care, medical and school supplies — to provide basic necessities and disaster relief to people in need in the U.S. and roughly 70 countries since 1991.

Leverages the skills of military veterans to rapidly deploy emergency response teams for disaster relief, providing mucking/gutting, debris removal, roof tarping, and long-term recovery operations.

Provides privately funded relief, reconstruction and development aid — centered on health and education — to communities in the U.S. and abroad affected by disasters and chronic poverty, with communities guiding where resources go.

Describes itself as the only full-time resource dedicated to helping donors increase the impact of their disaster giving, managing disaster funds and making grants focused on medium- and long-term recovery.

Provides disaster relief in the U.S. and abroad — food, clean water and hygiene items staged in regional distribution centers and international warehouses — plus children's feeding, agriculture and women's empowerment programs overseas.

Provides comprehensive behavioral health services — counseling, youth residential programs, housing assistance, school-based services, and recovery support — across 21 counties in southeastern and central Ohio, serving 15,000+ individuals annually.

Connects service members, veterans and their families — regardless of service era or discharge status — with trauma-informed mental health treatment through a network of clinical partners, starting with 30 cost-free therapy sessions.

Originated the clubhouse model — community spaces where people living with serious mental illness get meals, job training, education and housing help — and runs clubhouses in New York City and Los Angeles plus national policy, advocacy and research work.

Covers the cost of therapy for Black women and nonbinary people nationwide through its Therapy Fund, which pays for 4–12 sessions per recipient, and has offered professional development for therapists since 2021.

Describing itself as the only national 501(c)(3) focused on advocating for rural mental health equity, Rural Minds provides mental health information, education and stigma-reduction programs for rural America's 46 million residents, working through FFA, 4-H, schools and churches.

Presents hope and finds help for people struggling with depression, addiction, self-injury, and suicide, investing directly into treatment, recovery, and therapy scholarships.

Supports the mental health and emotional well-being of young people of color and those from underserved communities through partnerships, research and culturally competent resources, focusing on the transitions into college and the workforce.

Provides adult survivors of complex trauma with daily support between therapy appointments through peer recovery groups, a peer chat group, a healing book club, trauma-informed yoga, trauma-friendly meditation and a weekly creative group.

Since 1981, has worked alongside people facing homelessness and poverty in rural southeast Ohio, running the Timothy House — which it calls the only shelter for adults and children in eight rural counties — plus kids' programs and about 21,000 meals a year.

A domestic violence agency empowering survivors and their families through emergency shelter, a 24/7 crisis hotline, outreach counseling, court advocacy, housing support, and the My Sister's Paws pet safety program in SE Ohio.

Founded in 2014 by Lorena Vásquez and Yeinny Yanira Castro, provides psychosocial care, education and job help to 98 children and 98 young women from families living in Medellín's inquilinatos — rooming houses where whole families often share one room.

Combats homelessness through the power of running, community support, and essential employment and housing resources, operating in 14 U.S. cities.

Operates Community First! Village, a 51-acre master-planned community in Austin providing permanent housing, micro-enterprises, and supportive community for the chronically homeless.

Builds tiny home communities across America for the chronically homeless and disabled, providing permanent housing with wraparound support services and a strong community model.

Builds interim supportive housing across California on temporarily vacant land using prefabricated modular buildings, giving each resident a private, locking room and on-site services while they work toward permanent housing, typically over six to twelve months.

A Philadelphia nonprofit co-founded in 1989 that helps people break the cycle of homelessness and poverty through permanent supportive housing, street outreach, health care, employment programs and education.

Describing itself as the only national nonprofit focused solely on reducing military and veteran suicide, provides free, fully virtual care through its ROGER Wellness Service — pairing each client with a wellness coordinator and licensed clinicians — regardless of discharge status.

Empowers veterans and military spouses to succeed in the civilian workforce through free personalized career coaching, resume building, interview preparation, and employment workshops.

Addresses the personal and economic needs of women veterans and their children through emergency financial assistance, childcare cost help and professional development, continuing work that began in 1920 as a housing association for widows, war nurses and mothers of fallen service members.

Provides transitional and permanent housing, homelessness prevention, employment services and basic-needs help to homeless and at-risk veterans and their families, serving 400+ veteran households a year across 13 northern Illinois counties.

Founded by military wives in 2006, enhances the quality of life for post-9/11 service members and families through transition services, clinical health and wellness, sports and recreation, and community engagement.

Runs a five-month fellowship for veterans with service-connected disabilities, military spouses and caregivers that pairs a Georgetown University business certificate with hands-on bakery-business experience, now delivered mainly over Zoom to fellows across the U.S.

Trains veterans, active-duty service members and military spouses to become software and cloud engineers through Fullstack Engineering and AI Cloud & DevOps programs, in person or remote, with GI Bill eligibility, scholarships and career services.

Supports wounded, injured and ill veterans and active-duty Purple Heart service members from every branch, and their families, through support and assistance, hospital visits, scholarships, a healing arts program, internships and retreats at Heroes Ridge at Raven Rock.

UNCF (United Negro College Fund) raises money for 36 member private historically Black colleges and universities and awards more than 11,000 scholarships a year to help students pay for college.

The Thurgood Marshall College Fund supports students and schools across a network of 57 publicly supported HBCUs, community colleges, predominantly Black institutions, and medical and law schools through scholarships and career programs.

The NAACP Legal Defense and Educational Fund (LDF) is a civil rights law organization that uses litigation, advocacy, research, and public education to advance the rights of Black Americans in voting, education, criminal justice and economic justice.

The Equal Justice Initiative is a Montgomery, Alabama nonprofit that provides legal representation to people illegally convicted, unfairly sentenced, or abused in prisons, and runs museums and memorials documenting the history of racial injustice in America.

Black Girls Code is an Oakland-based nonprofit that teaches coding and technology skills, including AI and game design, to Black girls ages 7–18 through workshops, summer camps, and free online video lessons.

/dev/color is a nonprofit career accelerator for Black software engineers, technologists, and executives, running peer-mentorship squads, an executive accelerator, and a professional community to help members advance into senior and leadership roles.

Black Farmer Fund is a New York-based nonprofit that invests in Black-owned farms and food businesses across nine Northeast states through low-interest community notes, gifts, and technical support, to build community wealth in the Black food system.

BEAM (Black Emotional and Mental Health Collective) is a national nonprofit that trains, funds, and connects therapists, wellness practitioners, and community leaders to expand community-based mental health care and healing for Black communities.

A San Francisco–based nonprofit founded in 1990 that defends civil liberties online through impact litigation, policy analysis, grassroots activism, and free privacy and security tools such as Privacy Badger and Certbot.

The tax-deductible 501(c)(3) arm of the American Civil Liberties Union, funding the ACLU's litigation, communications, and public education on civil liberties issues such as free speech, voting rights, privacy, and criminal justice.

A San Antonio–based nonprofit founded in 1986 that provides immigration legal services, case management, refugee resettlement support, and bond assistance to immigrants and refugees, with offices in five Texas cities.

An Arizona nonprofit founded in 1989 that gives free legal help and social services to immigrant adults and unaccompanied children held in Arizona custody who face deportation proceedings, from know-your-rights sessions to full courtroom representation.

An international nonprofit founded in 2008 by Microsoft and Angelina Jolie that protects unaccompanied and separated migrant children through a network of pro bono lawyers, psychosocial support, and policy advocacy in the U.S., Mexico, and Europe.

An independent law and policy organization affiliated with NYU School of Law, founded in 1995, that works through research, litigation, and advocacy on voting and elections, criminal justice, civil liberties, and government accountability.

A national legal organization founded in 1973 that uses impact litigation, public education, and policy advocacy to pursue full civil rights for LGBTQ+ people and everyone living with HIV, without charging its clients.

A global legal advocacy organization founded in 1992 that uses litigation, legal policy work, and advocacy before national courts, UN committees, and regional human rights bodies to advance reproductive rights, including abortion and contraception access.

The 501(c)(3) charitable arm of Ohio's Buckeye Firearms Association, funding FASTER Saves Lives emergency-response training for school staff, youth shooting programs, grants to shooting and hunting programs, and legal defense for gun owners.

A 501(c)(3) grant-making foundation, known until 2026 as The NRA Foundation, that funds firearm safety and marksmanship training, youth shooting sports, hunter education, law enforcement training, conservation, and constitutional education.

A Bellevue, Washington–based nonprofit founded in 1974 that pursues gun-rights litigation, public education, and publications to promote understanding of the constitutional right to privately own and possess firearms.

The 501(c)(3) partner of Firearms Policy Coalition, supporting Second Amendment litigation, amicus briefs, research, and education, and providing legal oversight for FPC Law, the coalition's public interest legal program.

A nonprofit public interest law firm that represents people free of charge in constitutional cases involving property rights, economic liberty, free speech, and educational choice, founded in 1991 and based in Arlington, Virginia.

A nonprofit public interest law firm, founded in 1973, that represents Americans free of charge in cases against government overreach, with a focus on property rights and limits on regulatory power.

A Washington, D.C., nonprofit law firm founded in 1994 that litigates religious-liberty cases for clients of many faiths, with the stated aim of protecting the free expression of all faiths.

A private liberal arts college in Hillsdale, Michigan, founded in 1844, that declines federal and state taxpayer funding and offers the public free online courses and Imprimis, its free monthly speech digest.